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World of Statistics  

Nuno Henriques dos Santos Sepulveda
PhD in Biomedical Sciences (Universidade do Porto)

Investigador Auxiliar
London School of Hygiene and Tropical Medicine

Nuno Henriques dos Santos Sepulveda
  • PhD in Biomedical Sciences, Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, 2009.
  • MSc in Applied Mathematics, Instituto Superior Técnico, Universidade Técnica de Lisboa, 2004.
  • BSc in Applied Mathematics and Computation, Instituto Superior Técnico, Universidade Técnica de Lisboa, 2001.
Investigação: Assuntos de interesse:
  • Statistical methods for sero-epidemiological studies of infectious diseases
  • Study design of epidemiological studies
  • Statistical genetics of malaria
  • Statistical inference of rare events
Outras actividades Profissionais:
  • Co-investigator of the project "Zika virus surveillance in human and mosquito population in Cape Verde" (funded by MRC Zika Rapid Response Call, 2016-2017)
  • Co-investigator of the project "Feasibility of a serological assay for malaria elimination certification" (funded by Gates Foundation, 2016-2017)
  • Portuguese representative in the EUROMENE (European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome) cost action
  • Member of the steering committee of LSHTM Centre for Statistical Methodology
Disciplinas leccionadas:
  • Analysis and Design of Research Studies, London School of Hygiene and Tropical Medicine, 2011-2018.
  • Organiser of the course "Quantitative Methods" in PhD Programme in Integrative Biomedical Sciences (Instituto Gulbenkian de Ciência, 2013-2018).
  • Organiser of the course 'Statistics and Quantitative Biology" in Gulbenkian PhD Programa Gulbenkian for Development and Cooperation (Universidade de Cabo Verde, 2013-2017).
Publicações mais recentes:
  • Sepúlveda N, Phelan J, Diez-Benavente E, Campino S, Clark TG, Hopkins H, Sutherland C, Drakeley CJ, Beshir KB. Global analysis of Plasmodium falciparum histidine-rich protein-2 (pfhrp2) and pfhrp3 gene deletions using whole-genome sequencing data and meta-analysis. Infect Genet Evol. 2018 May 2. pii: S1567-1348(18)30226-0.
  • Voak AA, Standing JF, Sepúlveda N, Harris A, Croft SL, Seifert K. Pharmacodynamics and cellular accumulation of amphotericin B and miltefosine in Leishmania donovani-infected primary macrophages. J Antimicrob Chemother. 2018 Feb 28.
  • Ravenhall M, Campino S, Sepúlveda N, Manjurano A, Nadjm B, Mtove G, Wangai H, Maxwell C, Olomi R, Reyburn H, Drakeley CJ, Riley EM, Clark TG; in collaboration with MalariaGEN. Novel genetic polymorphisms associated with severe malaria and under selective pressure in North-eastern Tanzania. PLoS Genet. 2018 Jan 30;14(1):e1007172.
  • Guelbéogo WM, Gonçalves BP, Grignard L, Bradley J, Serme SS, Hellewell J, Lanke K, Zongo S, Sepúlveda N, Soulama I, Wangrawa DW, Yakob L, Sagnon N, Bousema T, Drakeley C. Variation in natural exposure to anopheles mosquitoes and its effects on malaria transmission. Elife. 2018 Jan 23;7. pii: e32625.
  • Migchelsen SJ, Sepúlveda N, Martin DL, Cooley G, Gwyn S, Pickering H, Joof H, Makalo P, Bailey R, Burr SE, Mabey DCW, Solomon AW, Roberts CH. Serology reflects a decline in the prevalence of trachoma in two regions of The Gambia. Sci Rep. 2017 Nov 8;7(1):15040.
Outras Publicações relevantes:
  • Beshir KB, Sepúlveda N, Bharmal J, Robinson A, Mwanguzi J, Busula AO, de Boer JG, Sutherland C, Cunningham J, Hopkins H. Plasmodium falciparum parasites with histidine-rich protein 2 (pfhrp2) and pfhrp3 gene deletions in two endemic regions of Kenya. Sci Rep. 2017 Nov 7;7(1):14718.
  • Sepúlveda N, Manjurano A, Campino SG, Lemnge M, Lusingu J, Olomi R, Rockett KA, Hubbart C, Jeffreys A, Rowlands K, Clark TG, Riley EM, Drakeley CJ; MalariaGEN Consortium. Malaria Host Candidate Genes Validated by Association With Current, Recent, and Historical Measures of Transmission Intensity. J Infect Dis. 2017 Jul 1;216(1):45-54.
  • Sepúlveda N, Stresman G, White MT, Drakeley CJ. Current Mathematical Models for Analyzing Anti-Malarial Antibody Data with an Eye to Malaria Elimination and Eradication. J Immunol Res. 2015;2015:738030.
  • Sepúlveda N, Paulino CD, Drakeley C. Sample size and power calculations for detecting changes in malaria transmission using antibody seroconversion rate. Malar J. 2015 Dec 30;14:529.
  • Sepúlveda N, Drakeley C. Sample size determination for estimating antibody seroconversion rate under stable malaria transmission intensity. Malar J. 2015 Apr 3;14:141.


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